Articles

The list below contains articles to which we contributed.

2024

224 M1-derived extracellular vesicles polarize recipient macrophages into M2-like macrophages and alter skeletal muscle homeostasis in a hyper-glucose environment (pdf, 8 MB)
Stefano Tacconi, Francesco Var, Carolina Sbarigia, Diana Vardanyan, Serena Longo, Francesco Mura, Federica Angilè, Audrey Jalabert, Ferninand Blangero, Assia Eljaafari, Laurence Canaple, Daniele Vergara, Francesco Paolo Fanizzi, Marco Rossi, Claire Crola Da Silva, Elizabeth Errazuriz‑Cerda, Christel Cassin, Rienk Nieuwland, Anna Maria Giudetti, Sophie Rome, and Luciana Dini
Cell Communication and Signaling 22 (193), 723 (2024)
223 Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches (external)
Joshua A. Welsh, Deborah C.I. Goberdhan, Lorraine O'Driscoll, Edit I. Buzas, Cherie Blenkiron, Benedetta Bussolati, Houjian Cai, Dolores Di Vizio, Tom A.P. Driedonks, Uta Erdbrügger, Juan M. Falcon-Perez, Qing-Ling Fu, Andrew F. Hill, Metka Lenassi, Sai Kiang Lim, Mỹ G. Mahoney, Sujata Mohanty, Andreas Möller, Rienk Nieuwland, Takahiro Ochiya, Susmita Sahoo, Ana C. Torrecilhas, Lei Zheng, Andries Zijlstra, Sarah Abuelreich et al.
Journal of Extracellular Vesicles 13 (2), e12404 (2024)
222 Poloxamer-188 as a wetting agent for microfluidic resistive pulse sensing measurements of extracellular vesicles
Mona Shahsavari, Rienk Nieuwland, Ton G. van Leeuwen, and Edwin van der Pol
PLoS One, in press.
221 Lipoprotein apheresis affects the concentration of extracellular vesicles in patients with elevated lipoprotein (a)
Joanna Marlęga-Linert, Aleksandra Gąsecka, Edwin van der Pol, Agnieszka Kuchta, Krzysztof J. Filipiak, Marcin Fijałkowski, Marcin Gruchała, Rienk Nieuwland, and Agnieszka Mickiewicz
Scientific Reports, in press.
220 Proteome encoded determinants of protein sorting into extracellular vesicles (pdf, 2 MB)
Katharina Waury, Dea Gogishvili, Rienk Nieuwland, Madhurima Chatterjee, Charlotte E. Teunissen, and Sanne Abeln
Journal of Extracellular Biology 3 (1), e120 (2024)
219 Recommendations for reproducibility of cerebrospinal fluid extracellular vesicle studies (pdf, 2 MB)
Ursula S. Sandau, Setty M. Magaña, Júlia Costa, John P. Nolan, Tsuneya Ikezu, Laura J. Vella, Hannah K. Jackson, Lissette Retana Moreira, Paola Loreto Palacio, Andrew F. Hill, Joseph F. Quinn, Kendall R. Van Keuren-Jensen, Trevor J. McFarland, Joanna Palade, Eric A. Sribnick, Huaqi Su, Kostas Vekrellis, Beth Coyle, You Yang, Juan M. Falcón-Perez, Rienk Nieuwland, Julie A. Saugstad, and nternational Society for Extracellular Vesicles Cerebrospinal Fluid Task Force
Journal of Extracellular Vesicles 13 (1), 12397 (2024)
218 A beginner’s guide to study extracellular vesicles in human blood plasma and serum (pdf, 1 MB)
Rienk Nieuwland, and Pia R.M. Siljander
Journal of Extracellulair Vesicles 13 (1), e12400 (2024)
217 Traceable characterization of hollow organosilica beads as potential reference materials for extracellular vesicle measurements with optical techniques (pdf, 3 MB)
Jérôme Deumer, Robin Schürmann, Anikó Gaál, Zoltán Varga, Britta Bettin, Edwin van der Pol, Rienk Nieuwland, David Ojeda, Aneta Sikora, Dorota Bartczak, Heidi Goenaga‑Infante, Johanna Noireaux, Mahrad Khakpour, Virpi Korpelainen, and Christian Gollwitzer
Discover Nano 19 (1), 14 (2024)

2023

216 Clinical applications and challenges in the field of extracellular vesicles (pdf, 11 MB)
Rienk Nieuwland, Agustin Enciso-Martinez, and Jillian W.P, Bracht
Medizinische Genetik 35 (4), 251-258 (2023)
215 MIBlood-EV: Minimal information to enhance the quality and reproducibility of blood extracellular vesicle research (pdf, <1 MB)
Fabrice Lucien, Dakota Gustafson, Metka Lenassi, Bo Li, Jacob J. Teske, Eric Boilard, on Hohenberg Katharina C. , alcón-Perez Juan M. , Alice Gualerzi, Antonia Reale, Jennifer C. Jones, Cecilia Lässer, Charlotte Lawson, Irina Nazarenko, Lorraine O'Driscoll, Ryan Pink, Pia R-M Siljander, Carolina Soekmadji, An Hendrix, Joshua A. Welsh, Kenneth W. Witwer, and Rienk Nieuwland
Journal of Extracellulair Vesicles 12 (12), 12385 (2023)
214 MicroRNAs in extracellular vesicles released from epicardial adipose tissue promote arrhythmogenic conduction slowing (pdf, 3 MB)
Auriane C. Ernault, Rosan de Winter, Benedetta Fabrizi, Jillian WP Bracht, Chi Hau, Shirley CM van Amersfoorth, Eva R. Meulendijks, Anke J. Tijsen, Lucía Cócera Ortega, Ingeborg van der Made, Aleksandra Gasecka, Antoine H. Driessen, Rienk Nieuwland, Bastiaan J. Boukens, Edwin van der Pol, Joris R. de Groot, and Ruben Coronel
Heart Rhythm O2 4 (12), 805-14 (2023)
213 Anti-high-mobility group box-1 treatment strategies improve trauma-induced coagulopathy in a mouse model of trauma and shock (pdf, 1 MB)
Pieter H. Sloos, M. Adrie W. Maas, Joost C.M. Meijers, Rienk Nieuwland, Joris J.T.H. Roelofs, Nicole P. Juffermans, and Derek J.B. Kleinveld
British Journal of Anaesthesia 130 (6), 687-697 (2023)
212 Plasma extracellular vesicle test sample to standardize flow cytometry measurements (pdf, 1 MB)
Britta Bettin, Edwin van der Pol, and Rienk Nieuwland
Research and Practice in Thrombosis and Haemostasis 7 (4), 100181 (2023)
211 Benchmarking blood collection tubes and processing intervals for extracellular vesicle performance metrics (pdf, 4 MB)
Bert Dhondt, Cláudio Pinheiro, Edward Geeurickx, Joeri Tulkens, Glenn Vergauwen, Edwin van der Pol, Rienk Nieuwland, Anneleen Decock, Ilkka Miinalainen, Pekka Rappu, Jo Vandesompele, Pieter Mestdagh, Nicolaas Lumen, Olivier de Wever, and An Hendrix
Journal of Extracellular Vesicles 12 (5), 12315 (2023)
210 Preventing swarm detection in extracellular vesicle flow cytometry - a clinically applicable procedure (pdf, 2 MB)
Naomi C. Buntsma, Mona Shahsavari, Aleksandra Gąsecka, Rienk Nieuwland, Ton G. van Leeuwen, and Edwin van der Pol
Research and Practice in Thrombosis and Haemostasis 7 (4), 100171 (2023)
209 Standardization of extracellular vesicle concentration measurements by flow cytometry: the past, present and future (pdf, 1 MB)
Britta Bettin, Zoltán Varga, Rienk Nieuwland, and Edwin van der Pol
Journal of Thrombosis and Haemostasis 21 (8), 2032-44 (2023)
208 Tissue factor activity of small and large extracellular vesicles in different diseases (pdf, 1 MB)
Ana T.A. Sachetto, Sierra J. Archibald, Yohei Hisada, Axel Rosell, Sebastian Havervall, Nick van Es, Rienk Nieuwland, Robert A. Campbell, Elizabeth A. Middleton, Matthew T. Rondina, Charlotte Thålin, and Nigel Mackman
Research and Practice in Thrombosis and Haemostasis 7 (3), 100124 (2023)
207 Isolation-free measurement of single urinary extracellular vesicles by imaging flow cytometry (pdf, 3 MB)
Liang Wu, Wouter W. Woud, Carla C. Baan, Dennis A. Hesselink, Edwin van der Pol, Guido Jenster, and Karin Boer
Nanomedicine: Nanotechnology, Biology and Medicine 48, 102638 (2023)
206 A compendium of single extracellular vesicle flow cytometry (pdf, 4 MB)
Joshua A. Welsh, Ger J.A. Arkesteijn, Michel Bremer, Michael Cimorelli, Françoise Dignat-George, Bernd Giebel, André Görgens, An Hendrix, Martine Kuiper, Romaric Lacroix, Joanne Lannigan, Ton G. van Leeuwen, Estefanía Lozano-Andrés, Shoaib Rao, Stéphane Robert, Leonie de Rond, Vera A. Tang, Tobias Tertel, Xiaomei Yan, Marca H.M. Wauben, John Nolan, Jennifer C. Jones, Rienk Nieuwland, and Edwin van der Pol
Journal of Extracellular Vesicles 12 (2), 12299 (2023)
205 Platelet removal from human blood plasma improves detection of extracellular vesicle-associated miRNA (pdf, 1 MB)
Jillian W.P. Bracht, Mandy Los, Monique A.J. van Eijndhoven, Britta Bettin, Edwin van der Pol, D. Michiel Pegtel, and Rienk Nieuwland
Journal of Extracellular Vesicles 12 (2), 12302 (2023)
204 Methods for the identification and characterization of extracellular vesicles in cardiovascular studies: from exosomes to microvesicles (pdf, 6 MB)
Sean M. Davidson, Chantal M. Boulanger, Elena Aikawa, Lina Badimon, Lucio Barile, Christoph J. Binder, Alain Brisson, Edit Buzas, Costanza Emanueli, Felix Jansen, Miroslava Katsur, Romaric Lacroix, Sai Kiang Lim, Nigel Mackman, Manuel Mayr, Philippe Menasché, Rienk Nieuwland, Susmita Sahoo, Kaloyan Takov, Thomas Thum, Pieter Vader, Marca H.M. Wauben, Kenneth Witwer, and Joost P.G. Sluijter
Cardiovascular Research 119 (1), 45-63 (2023)

2022

203 Automated fluorescence gating and size determination reduce variation in measured concentration of extracellular vesicles by flow cytometry (pdf, 1 MB)
Angela A.F. Gankema, Bo Li, Rienk Nieuwland, and Edwin van der Pol
Cytometry Part A 101 (12), 1049-56 (2022)
202 Shock-driven endotheliopathy in trauma patients is associated with leucocyte derived extracellular vesicles (pdf, 1 MB)
Romein, W.G. Dujardin, Jeske E.C. Kisters, Mathijs R. Wirtz, Najat Hajji, Anita M. Tuip-de Boer, Jakob Stensballe, Pär I. Johansson, Karim Brohi, Ross A. Davenport, Christine Gaarder, Simon Stanworth, Marc Maegele, Rienk Nieuwland, Edwin van der Pol, and Nicole P. Juffermans
International Journal of Molecular Sciences 23 (24), 15990 (2022)
201 Rapid and efficient isolation platform for plasma extracellular vesicles: EV-FISHER (pdf, 2 MB)
Wei-Lun Pan, Jun-Jie Feng, Ting-Ting Luo, Yong Tan, Bo Situ, Rienk Nieuwland, Jing-Yun Guo, Chun-Chen Liu, Han Zhang, Jing Chen, Wen-Hua Zhang, Jun Chen, Xian-Hua Chen, Hong-Yue Chen, Lei Zheng, Jin-Xiang Chen, and Bo Li
Journal of Extracellular Vesicles 11 (11), e12281 (2022)
200 Removal of platelets from blood plasma to improve the quality of extracellular vesicle research (pdf, 1 MB)
Britta Bettin, Aleksandra Gasecka, Bo Li, Bert Dhondt, An Hendrix, Rienk Nieuwland, and Edwin van der Pol
Journal of Thrombosis and Haemostasis 20 (11), 2679-85 (2022)
199 Extracellular vesicles from amniotic fluid, milk, saliva, and urine expose complexes of tissue factor and activated factor VII (pdf, 3 MB)
Yong Hu, Andreas Repa, Ton Lisman, Guelen Yerlikaya-Schatten, Chi Hau, Ingrid Pabinger, Cihan Ay, Rienk Nieuwland, and Johannes Thaler
Journal of Thrombosis and Haemostasis 20 (10), 2306-2312 (2022)
198 Coagulation signaling from amniotic fluid to fetal skin (pdf, 1 MB)
Yong Hu, Anke Scharrer, Chi Hau, Cihan Ay, René J. Berckmans, Wolfram Ruf, Rienk Niuewland, and Johannes Thaler
Blood advances 6 (19), 5538-5541 (2022)
197 Method to traceably determine the refractive index by measuring the angle of minimum deviation (pdf, 1 MB)
Martine Kuiper, Richard Koops, Rienk Nieuwland, and Edwin van der Pol
Metrologia 59 (5), 055006 (2022)
196 EDTA stabilizes the concentration of platelet-derived extracellular vesicles during blood collection and handling (pdf, <1 MB)
Naomi C. Buntsma, Aleksandra Gąsecka, Yvo B.W.E.M. Roos, Ton G. Leeuwen, Edwin, van der Pol, and Rienk Nieuwland
Platelets 33 (5), 764-71 (2022)
195 An imaging flow cytometry-based methodology for the analysis of single extracellular vesicles in unprocessed human plasma (pdf, 3 MB)
Wouter W. Woud, Edwin van der Pol, Erik Mul, Martin J. Hoogduijn, Carla C. Baan, Karin, Boer, and Ana Merino
Communications Biology 5 (633), 1-4 (2022)
194 Reproducibility of extracellular vesicle research (pdf, 1 MB)
Rienk Nieuwland, Pia R.M. Siljander, Juan M. Falcón-Pérez, and Kenneth W. Witwer
European Journal of Cell Biology 101 (3), 151226 (2022)
193 Calibration and standardization of extracellular vesicle measurements by flow cytometry for translational prostate cancer research (pdf, 4 MB)
Yohan Kim, Edwin van der Pol, Ali Arafi, Ishwor Thapa, Cameron Britton, Jorgena Kosti, Siyang Song, Vidhu B. Joshi, Ree Erickson, Hesham Ali, and Fabrice Lucien
Nanoscale 14, 9781-95 (2022)
192 Diagnostic performance of circulating miRNAs and extracellular vesicles in acute ischemic stroke (pdf, 2 MB)
Ceren Eyileten, Daniel Jakubik, Andleeb Shahzadi, Aleksandra Gąsecka, Edwin van der Pol, Salvatore De Rosa, Dominika Siwik, Magdalena Gajewska, Dagmara Mirowska-Guzel, Iwona Kurkowska-Jastrzębska, Anna Czlonkowska, and Marek Postula
International Journal of Molecular Sciences 23, 4530 (2022)
191 Intraperitoneal activation of coagulation and fibrinolysis in patients with cirrhosis and ascites (pdf, <1 MB)
Johannes Thaler, Ton Lisman, Peter Quehenberger, Lena Hell, Philipp Schwabl, Bernhard Scheiner, Theresa Bucsics, Rienk Nieuwland, Cihan Ay, Michael Trauner, Ingrid Pabinger, Thomas Reiberger, and Mattias Mandorfer
Thrombosis and Haemostasis 122 (03), 353-362 (2022)
190 Processing methods of donor human milk evaluated by a blood plasma clotting assay (pdf, 1 MB)
Yong Hu, Eva Kontopodi, Elise Mank, Chris H.P. van den Akker, Johannes B. van Goudoever, Kasper Hettinga, Ruurd M. van Elburg, Johannes Thaler, and Rienk Nieuwland
Innovative Food Science & Emerging Technologies 76, 102938 (2022)
189 Minimum information to report about a flow cytometry experiment on extracellular vesicles: communication from the ISTH SSC Subcommittee on Vascular Biology (pdf, 1 MB)
Edwin van der Pol, Joshua A. Welsh, and Rienk Nieuwland
Journal of Thrombosis and Haemostasis 20 (1), 245-51 (2022)

2021

188 Misinterpretation of solid sphere equivalent refractive index measurements and smallest detectable diameters of extracellular vesicles by flow cytometry (pdf, 1 MB)
Edwin van der Pol, Ton G. van Leeuwen, and Xiaomei Yan
Scientific Reports 11, 24151 (2021)
187 Updating MISEV: Evolving the minimal requirements for studies of extracellular vesicles (pdf, 1 MB)
Kenneth W. Witwer, Deborah CI Goberdhan, Lorraine O'Driscoll, Clotilde Théry, Joshua A. Welsh, Cherie Blenkiron, Edit I. Buzás, Dolores Di Vizio, Uta Erdbrügger, Juan M. Falcón-Pérez, Qing-Ling Fu, Andrew F. Hill, Metka Lenassi, Jan Lötvall, Rienk Nieuwland, Takahiro Ochiya, Sophie Rome, Susmita Sahoo, and Lei Zheng
Journal of Extracellular Vesicles 10 (14), e12182 (2021)
186 Extracellular Vesicles in Human Milk (pdf, 2 MB)
Yong Hu, Johannes Thaler, and Rienk Nieuwland
Pharmaceuticals 14 (10), 1050 (2021)
185 Platelets are hyperactivated but show reduced glycoprotein VI reactivity in COVID-19 patients (pdf, <1 MB)
Valentine Léopold, Liza Pereverzeva, Alex R. Schuurman, Tom DY Reijnders, Anno Saris, Justin de Brabander, Christine CA van Linge, Renée A. Douma, Osoul Chouchane, Rienk Nieuwland, Joost W. Wiersinga, Cornelis van 't Veer, and Tom van der Poll
Thrombosis and Haemostasis 121 (09), 1258-1262 (2021)
184 Mesenchymal stem cell-derived extracellular vesicles conditionally ameliorate bone marrow failure symptoms in an immune-mediated aplastic anemia mouse model (pdf, 2 MB)
Mohammad A. Gholampour, Saeid Abroun, Rienk Nieuwland, Seyed J. Mowla, and Sara Soudi
Journal of Cellular Physiology 236 (8), 6055-6067 (2021)
183 Estradiol-driven metabolism in transwomen associates with reduced circulating extracellular vesicle microRNA-224/452 (pdf, 8 MB)
Barend W. Florijn, Jacques M.G.J. Duijs, Maartje Klaver, Eline N. Kuipers, Sander Kooijman, Jurrien Prins, Huayu Zhang, Hetty C.M. Sips, Wendy Stam, Maaike Hanegraaf, Ronald W.A.L. Limpens, Rienk Nieuwland, Bas B. van Rijn, Ton J. Rabelink, Patrick C.N. Rensen, Martin den Heijer, Roel Bijkerk, and Anton Jan van Zonneveld
European Journal of Endocrinology 185 (4), 539-552 (2021)
182 Quantification of light scattering detection efficiency and background in flow cytometry (pdf, 1 MB)
Leonie de Rond, Frank A.W. Coumans, Joshua A. Welsh, Rienk Nieuwland, Ton G. Leeuwen, and Edwin van der Pol
Cytometry Part A 99 (7), 671-9 (2021)
181 ADAM9-Responsive mesoporous silica nanoparticles for targeted drug delivery in pancreatic cancer (pdf, 10 MB)
E.J. Slapak, L. Kong, M. El Mandili, R. Nieuwland, A. Kros, M.F. Bijlsma, and C.A. Spek
Cancers 13 (13), 3321 (2021)
180 Novel mechanism regulating tissue factor activity (pdf, 1 MB)
Rienk Nieuwland
Blood 138 (4), 289-291 (2021)
179 Platelet removal by single-step centrifugation (pdf, 1 MB)
Linda G. Rikkert, Frank AW Coumans, Chi M. Hau, Leon WMM Terstappen, and Rienk Nieuwland
Platelets 32 (4), 440-443 (2021)
178 MIFlowCyt-EV: The next chapter in the reporting and reliability of single extracellular vesicle flow cytometry experiments (pdf, 1 MB)
Joshua A. Welsh, Vera A., Tang, Edwin van der Pol, and André Görgens
Cytometry Part A 99 (4), 365-8 (2021)
177 Secreted therapeutics: monitoring durability of microRNA-based gene therapies in the central nervous system (pdf, 2 MB)
Marina Sogorb-Gonzalez, Carlos Vendrell-Tornero, Jolanda Snapper, Anouk Stam, Sonay Keskin, Jana Miniarikova, Elisabeth A. Spronck, Martin de Haan, Rienk Nieuwland, Pavlina Konstantinova, Sander J. van Deventer, Melvin M. Evers, and Astrid Vallès
Brain Communications 3 (2), fcab054 (2021)
176 Standardized procedure to measure the size distribution of extracellular vesicles together with other particles in biofluids with microfluidic resistive pulse sensing (pdf, 3 MB)
Michael Cimorelli, Rienk Nieuwland, Zoltán Varga, and Edwin van der Pol
PLoS One 16 (4), e0249603 (2021)
175 Prostacyclin analogues inhibit platelet reactivity, extracellular vesicle release and thrombus formation in patients with pulmonary arterial hypertension (pdf, 1 MB)
Aleksandra Gąsecka, Marta Banaszkiewicz, Rienk Nieuwland, Edwin van der Pol, Najat Hajji, Hubert Mutwil, Sylwester Rogula, Wiktoria Rutkowska, Kina Pluta, Ceren Eyileten, Marek Postula, Szymon Darocha, Zenon Huczek, Grzegorz Opolski, Krzysztof J. Filipiak, Adam Torbicki, and Marcin Kurzyna
Journal of Clinical Medicine 10, 1024 (2021)