Discoveries
- Extracellular vesicles (EVs) have a lower effective refractive index than lipoproteins.
- EV size distributions follow a power-law function.
- Hollow organosilica beads and EVs have similar optical properties.
- “Platelet-free plasma” contains 1 million platelets per mL.
- Residual platelets in plasma affect down-stream analysis of “EVs”.
- Size-exclusion chromatography can enrich EVs relative to lipoproteins and proteins.
- Swarm detection of EVs by flow cytometry.